This Regiment was also known as the "Johnson County Regiment" and was organized at Iowa City.  Men were mustered in on September 9, 1862 and served for three years.  Companies A, B, F, G, H, I and K were credited to Johnson County. Companies C, D and E were credited to Jasper, Monroe and Wapello, respectively. A total of  1084 men served in the 22nd Iowa during it's existence at one time or another. The Regiment was mustered out in Savannah, Georgia on July 25, 1865.

After garrison duty in Missouri, the regiment served in Gen. Ulysses S. Grant's Vicksburg Campaign of 1863. The regiment was one of the first ashored in Mississippi after the river crossing on April 30, 1863, and was the only Union unit to breach the defenses of Vicksburg, MS during the general assault of May 22, 1863. In late 1863 and early 1864, the regiment participated in operations on the Texas Gulf Coast and in Louisiana. In May 1864, it was ordered to Virginia. The 22nd was one of only three regiments from Iowa to serve in Virginia, including during  Gen. Philip Sheridan's Shenandoah Valley Campaign of August - November 1864. It suffered heavy losses at the Third Battle of Winchester and the Battle of Cedar Creek.

The Regiment suffered 250 fatalities. They included 6 officers and 108 enlisted men who were killed in action or died of their wounds and 1 officer and 135 enlisted men who died of disease.
Source: Wikipedia, the free encyclopedia