Dr. Enos Mitchell, one of the physicians of Grand River, Iowa, was orphaned at an early age, in Illinois, but grew to manhood living with various brothers who had moved to the Decatur and Clarke County, Iowa, area. He was a graduate of the Medical College of Keokuk, Iowa, and began practice at Garden Grove, in 1879.

In 1879 he was married to Emma Hogue, whose father had come from Scotland to farm near Weldon, Iowa. Dr. and Mrs. Mitchell moved into Weldon about 1885, building the first residence which had plastered walls and other "modern" conveniences. They raised two children here. Mrs. Mitchell built and operated a drugstore from 1887 to 1907, a block from the railroad depot, where trains ran both directions twice daily, and Dr. Mitchell's office was next door, both on the west side of main street. This building later burned.

For a short time they lived in Osceola, Iowa, where he purchased the first car sold in that county, a Holsman, which looked like a buggy, and had solid rubber wheels.

In the fall of 1915, Dr. Enos Mitchell and his wife, Emma Hogue Mitchell, moved from Weldon to Grand River, Iowa. They purchased a house, still in use, located across the street from the northwest corner of the park, and lived there from 1915 until his death, in 1940. His first office was over a bank on the west side of Main street.

Mrs. Mitchell was a registered pharmacist, but after selling her Weldon drugstore in 1907, for health reasons, she retired.

Their only son, Clairemont Hogue Mitchell, also a medical doctor, practiced in Leon, Iowa from 1910 to 1928, with an obstetrician specialty. During this time he volunteered and saw World War I service with the U.S. ARmy, in France. Both Dr. C. H. Mitchell and his father, Dr. Enos Mitchell, helped to secure the first hospital in Leon, Ia.

Their only daughter, Ena, lived with them and was Grand River High School principal for the 1916-17 school term. Besides teaching, she accompanied the sports teams to nearby towns, taking them to sports events on the trains which ran daily. In the fall of 1917 she married a farmer, Robert Birlingmair, eldest son of Henry Birlingmair of Weldon and later Humeston, in a home wedding and outdoor reception at the Mitchell residence in Grand River. While she and her husband were farming land in South Dakota, owned by Mrs. Mitchell and by her sister, Viola Hogue, who lived with the Mitchells, Mrs. Birlingmair returned to Grand River for the birth of two of her children delivered by Dr. Mitchell. He also travelled to South Dakota to deliver two more of the six grandchildren, and a final delivery of a grandson in Iowa.

Dr. Mitchell had become well known for his successful diagnoses, and was frequently called for consultation, even to Des Moines, where again train travel was the common and quickest route. He also was a successful surgeon. In addition, he was mayor for approximately thirteen years, and he and his wife belonged to the Grand River Methodist church, where earlier his older brother, George, had been minister.

Mrs. Mitchell died at age 78, in their home, in 1934. Dr. Mitchell practiced in Grand River from 1915 until 1939, when he lived with his daughter on their farm near Primghar, in O'Brien county, in northwest Iowa, passing away in her home in 1940 at the age of 86.